The 43-year-old’s time in the Premier League has included spells with Liverpool, Blackburn and Aston Villa.
He joined Tottenham in 2011, but has been back-up to Hugo Lloris since the Frenchman’s arrival the following year.
Friedel said on the Tottenham website: I’m incredibly proud of what I’ve achieved in my career. When I first started the journey I never imagined it would be this long, playing 23 seasons in total and representing some incredible clubs.’
Friedel, who won 82 caps for the United States, will return to America become an analyst, pundit and co-commentator for Fox Sports and will also be Tottenham’s club ambassador there.
He added: ‘One thing I will miss is that day-to-day interaction with the staff and players. There really is nothing like it but my 44th birthday is here so I think it is a good time to call it a day.
‘I’ve got some wonderful opportunities in front of me working for Fox TV and I’m completing my pro licence.
‘I’ve also signed on as a club ambassador for Spurs focusing on the USA. I’ve got a great relationship with the staff and board, so I’ll certainly do my bit to help the club go further.