Holders Real Madrid are without France striker Karim Benzema for the first leg of their Champions League semi-final against Italian champions Juventus.
Benzema, 27, has scored 22 goals for the Spanish club this season, but will not play in Turin after failing to recover from a knee injury.
Gareth Bale is set to start after returning as a substitute in Saturday’s win at Sevilla following a calf injury.
Juve pair Andrea Pirlo and Giorgio Chiellini are expected to start.
The veteran Italy internationals were both dropped to the bench as the Bianconeri won 1-0 at Sampdoria to clinch their fourth successive Serie A title.
Pirlo, 35, is set to renew acquaintances with Real Madrid boss Carlo Ancelotti, who managed the midfielder during a successful eight-year spell at AC Milan.
The pair helped the Rossoneri win a Serie A title, two Champions Leagues and the Club World Cup between 2001 and 2009, before Ancelotti left the San Siro to take over at Chelsea.
“He’s like a father to me,” said Pirlo.
“We worked together for many years, he gave me my chance in top-level football and changed my position.