With just two games to go, the relegation battle and the quest for the ultimate trophy would be the focus of most of the teams.
League leaders Ashantigold will play WAFA at the Obuasi Len Clay Sports Stadium in their quest to win the league with a game to spare.
A win would guarantee them the ultimate trophy as they currently have four points separating them from second-placed Aduana Stars.
Aduana will come against Edubiase in another tough encounter, while Heart of Lions would come against Accra Great Olympics at Kpando.
Kumasi Asante Kotoko travel to Sekondi to battle it out with Sekondi Hasaacas, while BA United host Liberty Professionals at the Carl Reindorf Park.
In another crucial game, relegation-threatened Accra Hearts of Oak would clash with Berekum Chelsea in their quest to escape relegation.
A slip would be disastrous for Hearts as they need to win their next two games in order to remain in the league.
At the Tema Park, Inter- Allies would play Bechem United while FA Cup winners Medeama SC come against Wa All Stars.
All games would be keenly contested as the results could decide the fate of many teams both at the top of the league table as well as at the bottom of it.
By Michael D. Abayateye